It's unsure if keeper Ron-Robert Zieler or full back Kurt Robinson will be in the matchday 16.
Andy Todd will continue in defence after his move from Derby.
Abdul Osman is back in full training and could be in contention. Danny Jackman took a knock on Tuesday and faces a late fitness test.
Town are definately without Bayo Akinfenwa, Colin Larkin and Chris Doig.
Colchester have added two new players to their squad ahead of their visit to Sixfields.
Jimmy Walker, a keepr has signed from West Ham and Marc Tierney has joined from Shrewsbury Town.