It will be a tough task for the Cobblers with League form very poor at the moment. But it's a cup game and anything can happen.
Sunderland manager Roy Keane is wary not to write off Northampton.
"Northampton's attitude will be that they're under no pressure, they've got nothing to lose," he said.
"People will be automatically expecting us to win this game of football but I've been at the end of one or two upsets and that's why everyone loves this cup football business.
"On the day, if the top teams don't approach it in the right way they will get beaten, and it's a test for any professional."