The game is a third midweek fixture in a row for Northampton and comes on the back of a long trip to Hartlepool United on Saturday where the record-breaking run of victories came to an end but another point was tucked away in the promotion cabinet.
Town still have an 18-point lead over Accrington Stanley in fourth place and a 10-point gap to nearest challengers Plymouth Argyle.
Chris Wilder admitted his side were not at the best at the Victoria Ground but gave credit to Hartlepool for their performance.
Being top of the table and there to be shot at has been Northampton's challenge for some weeks now and they have dealt with it admirably.
Wimbledon are the next to try, the Dons currently just one place outside the play-off spots after a defeat at home to Oxford United on Saturday that manager Neal Ardley felt was harsh on his side.
He told http://www.afcwimbledon.co.uk that: "The stats do not tell us that Oxford were better than us.
"The stats tell us that their keeper, a bit of luck, and poor finishing has cost us getting something from the game."