The Quakers are seemingly destined for the drop despite some improved displays in 2010 but will make Northampton fight all the way if Ian Sampson's side are to take a crucial three points in their play-off push.
"We know we've been knocking on the door with our performances," said boss Steve Staunton after seeing his men hold Bury to a 1-1 draw at Gigg Lane in midweek.
Recent signing Tadgh Purcell will be the man to watch for the Cobblers defence.
The 25-year-old Irishman has netted 7 goals in 11 league games including the opening goal at the Northern Echo Arena in late January from which Northampton recovered to win 2-1.