Chris Wilder's side play League One Millwall in the 2nd Round of the Johnstone's Paint Trophy on the back of an excellent 3-2 victory away to Wycombe Wanderers on Saturday that knocked the Chairboys off the top of League Two.
The Lions suffered a 5-3 defeat at Peterborough United on Saturday but are not in action this coming weekend so manager Neil Harris is set to name the strongest side at his disposal.
He will be without, however, midfielders Ed Upson and Jimmy Abdou after both players were forced off injured at London Road.
Competition rules prevent managers making too many changes but Chris Wilder may try and shuffle his pack slightly for another tough away fixture.
John-Joe O'Toole will surely get another chance to impress, though, after the midfielder earned special praise on Saturday from the manager who had previously said O'Toole had no future at Sixfields.