The Silkmen return to Moss Rose in good spirits after picking up four points from away fixtures at Torquay United and Crewe Alexandra over the past week.
Simpson has increased options at his disposal with the return of some players from injury and told his club's official website that changes may be on the cards.
"I'll have a think about that overnight," he said.
"I've read all the reports we've had on Northampton and spoken to people who have seen them this season."
Last season's corresponding fixture ended in a 2-0 win for the Cobblers as they continued their impressive post-Christmas form.