While the Cobblers have some cautious optimism after their win over AFC Wimbledon last week, Macclesfield have been drawn into the relegation scrap following seven successive defeats.
Manager Gary Simpson also has to contend with a lengthy injury list and said after the reverse against Aldershot: "If we had had a fully fit squad we could have put some points on the board in that time, but unfortunately for us things have gone against us and we are just trying our best.
"I don't want to let the players get down. I've got to keep them up and be positive but it's difficult, especially today, as I think this was a game we could have won."
Check out the head-to-head record of the two sides by clicking below.