The game will settle the final outstanding issue in League Two after York City clinched the second promotion place from the Blue Square Premier last weekend.
Cheltenham were 3-2 winners at Sixfields early on in the season before being held by Aidy Boothroyd's improving side at the start of March.
Crewe drew 1-1 on their visit to Northampton in December with the two teams playing out a similar scoreline at Gresty Road at the end of March.
Former Town manager Ian Sampson meanwhile has made a return to the game as the new boss of Corby Town.
Sampson, also a popular player with the Cobblers, takes over at the Blue Square North club with a brief to try and take the Steelmen into the top division of non-league football.