The 22-year-old scored a superb televised winner at Bristol Rovers on Sunday afternoon to lift Oxford to 4th in the League Two table, not the first stunner that the former West Bromwich Albion man has netted this season, but sustained a shoulder injury later in the game.
Speaking to the Oxford Mail however, goalkeeper Sam Slocombe believes the U's have the players replace Roofe.
it provides Ruffs (Josh Ruffels) or Johnny Lundstram with opportunities to come in and show what they can do.
“Rosey (Danny Rose) is very versatile and he can play wide. We’ve also got Callum (O’Dowda) to come back off international duty and he’s been brilliant for the last couple of games."
Chris Wilder, meanwhile, faces his former club, has said he understands the frustrations of Northampton supporters who will protest peacefully during the game under the #WeWantAnswers as fans seek more information about the future direction of the Cobblers.