The 23-year-old midfielder was sent-off for a 68th-minute tackle on Vale's Doug Loft but the Cobblers boss insists his player did nothing wrong.
Sampson said: "The appeal is in.
"We saw it straight after the game on DVD and it shows the ball changed direction. He won the ball and it was just a good tackle.
"The referee said he was sent off for a two-footed tackle but we disagree. He tackled with his right foot and the DVD evidence shows his left foot is a yard or so away from the player and his tackling foot.
"I think we have got as good a case as we did for his previous sending off which was overturned so we will just have to wait and see what happens."
Source: PA
Source: PA