The game of the day in League Two sees the Cobblers, out on top after last weekend's 4-3 win at Luton Town, against the pre-season promotion favourites.
Pompey are starting to find their stride and put four past Hartlepool United in their last match and a big crowd is expected at Sixfields for a pre-Christmas cracker.
Speaking to the official NTFC website ahead of the game, Chris Wilder said: "Everybody is okay from last weekend.
"The team is playing well at the moment and I don’t see us making too many changes."