The Cobblers have won 35 of the 87 meetings to date including 11 away from home.
Last season's corresponding game, in early October, ended in a 3-1 win for the home side after Anthony Charles was sent off for Town early in the game.
Aidy Boothroyd has seen his side have a man dismissed in both their away league games this season and knows that any repeat will harm their chances of improving their form on the road.
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Rovers head into the match in good spirits after a 3-2 win against York City last weekend.